科研成果

日期:2014-11-08 10:10

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2019

Effective oral delivery of gp100 plasmid vaccine against metastatic melanoma through multi-faceted blending-by-blending nanogelsJun Fu, Liyan Qiu*,Nanomedicine: Nanotechnology, Biology and Medicine, 2019.(pdf)


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2018
Photo-crosslinked and esterase-sensitive polymersome for improved antitumor effect of water-soluble chemotherapeuticsYurun Shen, Liyan Qiu*,Nanomedicine, 2018.(pdf)

Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes, Menghua Gao, Yan Peng, Liming Jiang, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology and Medicine, 2018.(pdf)

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Dual-responsive recurrent self-assembly of a supramolecular polymer based on the host-guest complexation interaction between  β-cyclodextrin and azobenzene , Ping Shen, Liyan Qiu*, New Journal of Chemistry, 2018.(pdf)

Design of pH-Sensitive Nanovesicles via cholesterol analogue incorporation for improving in vivo delivery of chemotherapeutics, Lina Liang, Jun Fu, Liyan Qiu*, ACS Applied Materials & Interfaces, 2018.(pdf)


2017

Optimizing Hydrophobic Groups in Amphiphiles to Induce GoldNanoparticle Complex Vesicles for Stability Regulation, Jun Fu, Liyan Qiu*, Langmuir, 2017.(pdf)

Loading docetaxel in β-cyclodextrin-based micelles for enhanced oral chemotherapy through inhibition of P-glycoprotein mediated efflux transport, Lu Zhang, Yurun Shen, Liyan Qiu*, RSC Advances, 2017.(pdf)

Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles With Improved Inhibition Effect Toward S180 Tumors, Yurun Shen, Liping Wu, Liyan Qiu*, Journal of pharmaceutical sciences, 2017.(pdf)

In Situ Generated Gold Nanoparticle Hybrid Polymersomes for Water-Soluble Chemotherapeutics: Inhibited Leakage  and pH-Responsive Intracellular Release, Jun Fu, Lina Liang, Liyan Qiu*, Advanced Functional Materials, 2017.(pdf)

2016

Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cance, Yan Peng, Xiumei Zhu, Liyan Qiu*, Biomaterials, 2016, 106: 1-12.(pdf)

Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal, Jing Xu, Xiumei Zhu,Liyan Qiu*, International journal of pharmaceutics, 2016, 498(1): 70-81.(pdf)


Constructing  aptamer anchored  nanovesicles  for  enhanced  tumor penetration  and  cellular uptake of  water soluble chemotherapeutics, Xin Li, Xiumei Zhu, Li Yan Qiu*, Acta Biomaterialia, 2016,35: 269-279 (pdf)

Reverse micelles-in-microspheres with sustained release of water-soluble combretastatin A4 phosphate for S180 tumor treatment, Liping Wu, Liyan Qiu*, Journal of Materials Chemistry B, 2016, 4(4): 760-767.(pdf)

Polymersomes via Self-Assembly of Amphiphilic β-Cyclodextrin-Centered Triarm Star Polymers for Enhanced Oral Bioavailability of Water-Soluble Chemotherapeutics, Mengying Hu, Yurun Shen, Lu Zhang,Liyan Qiu*, Biomacromolecules, 2016, 17(3): 1026-1039.(pdf)

Mechanism study of PEGylated polyester and β-cyclodextrin integrated micelles on drug resistance reversal in MRP1-overexpressed HL60/ARD cells, Qian Ji, Liyan Qiu*, Colloids and Surfaces B: Biointerfaces, 2016, 144: 203-213 (pdf)

Weakly cationic polyphosphazene vesicles for cancer immunotherapy by efficient in vivo cytokine IL-12 plasmid DNA delivery, Menghua Gao, Xiumei Zhu, Liping Wu, Liyan Qiu, Biomacromolecules, 2016, 17(6), 2199-2209(pdf)

Optimizing particle size of docetaxel-loaded micelles for enhanced treatment of oral epidermoid carcinoma, Yang Yu, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology, and Medicine, 2016,12: 1941-1949 (pdf)

Multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Menghua Gao, Yuzhen Xu, Liyan Qiu*, , Journal of Liposome Research (pdf)

Synergistic effects of A-B-C type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma, Lu Zhang, Jiafei Lu, Liyan Qiu*, International Journal of Nanomedicine (pdf)

Reversal of P-glycoprotein-mediated multidrug resistance by doxorubicin and quinine co-loaded liposomes in tumor cells, Qiying Shen, Liyan Qiu*,  Journal of Liposome Research, 2016: 1-9.

Sequentially dual-targeting vectors with nano-in-micro structure for improved docetaxel oral delivery in vivo, Yurun Shen,  Mengying Hu, Liyan Qiu*, Nanomedicine (pdf)

2015
Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy Nasopharyngeal Epidermal Carcinoma,  Jinfang Zhu, Xiaoping Xu, Mengying Hu, Liyan Qiu*, Journal of biomedical nanotechnology, 2015, 11(6): 997-1006.(pdf)
Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroquine co-delivery via liposomes, Menghua Gao, Yuzhen Xu, Liyan Qiu*, International journal of nanomedicine, 2015, 10: 6615.(pdf)

Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when coencapsulated with quinine in liposomes, Yuzhen Xu, Liyan Qiu*, International journal of nanomedicine, 2015, 10: 4225. (pdf)

Thermo-responsive triblock copolymer micelles containing PEG 6000 for either water-soluble or water-insoluble drug sustained release and treatment, Jun Fu, Xinyi Lv, Liyan Qiu*, RSC Advances, 2015, 5(47): 37451-37461.(pdf)
Indocyanine green targeted micelles with improved stability for near-infrared image-guided photothermal tumor therapy, Lu Yan, Liyan Qiu*, Nanomedicine, 2015, 10(3): 361-373.(pdf)
Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles, Xin Li, Yang Yu, Qian Ji ,Liyan Qiu*,Nanomedicine: Nanotechnology, Biology and Medicine ,2015, 11(1): 175-184.(pdf)
2014

The anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivates, Yang Yu, Xiaoli Zhang, Liyan Qiu*, Biomaterials 2014, 35:3467-3479 (pdf)

High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy, Jing Xu, Qinghe Zhao, Yangmin Jin, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology and Medicine, 2014,10(2): 349-358 (pdf)
2013
Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy, Xin Li, Qinghe Zhao, Liyan Qiu*, Journal of Controlled Release, 2013, 171(2): 152-162 (pdf)
Thermosensitive β-cyclodextrin modified poly(e-caprolactone)-poly(ethylene glycol)- poly(e-caprolactone) micelles prolong the anti-inflammatory effect of indomethacin following local injection,Xiawei Wei, Xinyi Lv, Qinghe Zhao, Liyan Qiu*,Acta Biomaterialia 2013, 9: 6953-6963 (pdf)
2013年以前
Mechanisms of drug resistance reversal in dox-resistant MCF-7 Cells by pH-responsive amphiphilic polyphosphazene containing diisopropylamino side groups, Li Yan Qiu*, Cheng Zheng and Qinghe Zhao, Molecular Pharmaceutics, 2012, 9(5): 1109-1117 (pdf)
β-cyclodextrin-centered star-shaped amphiphilic polymers for doxorubicin delivery,Li Yan Qiu*, Rong Juan Wang, Cheng Zheng, Yi Jin, Le Qun Jin,Nanomedicine, 2010, 5 (2): 193-208 (pdf)
Versatile preparation of fluorescent particles based on polyphosphazenes: from micro- to nanoscale, JiangxiangZhang*, Liyan Qiu*, Xiaodong Li, Yi Jin and Kangjie Zhu, Small, 2007, 3(12), 2081-2093 (pdf)
Self-assembled polyethylenimine-graft-poly(ε-caprolactone) micelles as potential dual carriers of genes and anticancer drugs, Li Yan Qiu, You Han Bae, Biomaterials,2007 (28): 4132-4142 (pdf)
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation, Jian Xiang Zhang, Xiao Jing Li, Li Yan Qiu*, Xiao Hui Li, Mei Qiu Yan, Yi Jin and Kang Jie Zhu,Journal of Controlled Release, 2006, 116 (3): 322-329 (pdf)
Multi-morphological self-assemblies of amphiphilic graft polyphosphazenes with oligo-poly (N-isopropylacrylamide) and ethyl 4-aminobenzoate as side groups,Jian Xiang Zhang, Li Yan Qiu, Yi Jin, Kang Jie Zhu, Macromolecules 2006,39,451-455 (pdf)

Thermosensitive micelles self-assembled by novel N-isopropylacrylamide oligomer Grafted Polyphosphazene, Jian Xiang Zhang, Li Yan Qiu*, Kang Jie Zhu, Yi Jin, Macromolecular Rapid Communications 2004, 25: 1563–1567 (pdf)

著作
Biopolymers,Volume 9: Miscellaneous Biopolymers and Biodegradation of Synthetic Polymers,Chapter 22:Biodegradation of polyphosphazenes 491-522, KJ Zhu,LY Qiu,Wiley-VCH出版社, 2003
Biomedical Applications of Polyphosphazenes, 15 Amphiphilic Polyphosphazenes as Drug Carriers, Liyan Qiu, Cheng Zheng, 277-296, Wiley出版社,2009年6月


代表性授权专利
肠定向释药微球制剂的制备方法 (ZL200310122947.1) 邱利焱
胸腺素口服肠溶微球及制备方法 (ZL200510049015.8)邱利焱, 杨巨飞
一种两亲性聚膦腈及制备和应用 (ZL200710070630.6)邱利焱
氯喹脂质体冻干粉针及制备方法(ZL200810098922.5)邱利焱,荆娜
一种两亲性环糊精聚合物及制备方法和用途(ZL200810062355.8)邱利焱,金乐群
pH响应型两亲接枝聚膦腈及其合成方法(ZL201010118025.3)邱利焱, 郑程
氯喹和阿霉素共载脂质体及其制备方法(ZL201110025330.2) 邱利焱,姚铭飞
一种包载亲水性药物的微球制剂及其制备方法(ZL201110209786.4)邱利焱,于洋,朱金芳
一种温敏两亲性环糊精聚合物及制备方法和用途(ZL201110209957.3),邱利焱,吕辛怡,魏霞蔚
氯喹类药物和紫杉醇类药物共载脂质体及其制备方法(ZL201210336602.5),邱利焱,高梦华





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