科研成果

2024年

PDGFR-targeted nanovesicles for restraining breast cancer hepatic metastasis via hepatic stellate cell

 regression and NK cell activation. Mengjie Kong, Yan Peng, et al. Liyan Qiu*. Materials Today, 2024.（accepted)

Rigid nanoparticles for efficient tumor immunotherapy through mechanical force mediated reprogramming of 

tumor-associated macrophages. Zhihuang Zhang, Yan Peng, Liyan Qiu*. Chemical Engineering Journal, 2024. (pdf)

pH-Sensitive degradable poly(ortho ester)-polyesters as injectable viscous fluid for long-acting rheumatoid 

arthritis treatment. Zhicheng Liao,Cheng Zheng, Liyan Qiu*.Acs Applied Polymer Materials, 2024. (pdf)

2023年

Sequential diagnosis and treatment for colon cancer via derived iridium and indocyanine green hybrid 

nanomicelles. Liang Yu, Yan Peng, Linping Jiang, Liyan Qiu*. ACS Applied Materials & Interfaces, 2023. (pdf)

Oligochitosan-based nanovesicles for nonalcoholic fatty liver disease treatment via the FXR/miR-34a/SIRT1 

regulatory loop. Mengjie Kong, Yan Peng, Liyan Qiu*.Acta Biomaterialia. 2023. (pdf)

2022年

Drug-induced self-assembled nanovesicles for doxorubicin resistance reversal via autophagy inhibition and 

delivery synchronism, Juan Wang, Liyan Qiu*, Theranostics, 2022. (pdf)

Responsive oligochitosan nano-vesicles with ursodeoxycholic acid and exenatide for NAFLD synergistic 

therapy via SIRT1, Pengchao Xie, Yan Peng, Liyan Qiu*, Carbohydrate Polymers, 2022. (pdf)

Near infrared light triggered ternary synergistic cancer therapy via L-arginine-loaded nanovesicles with 

modification of PEGylated indocyanine green, Kesi Wang, Linping Jiang, Liyan Qiu*, Acta Biomaterialia, 2021. (pdf)

Vesicular IFN-γ as a cooperative attacker to enhance anti-cancer effect of 5-fluorouracil via thymidine 

phosphorylase upregulation and tumor microenvironment normalization, Yan Peng, Yumiao Hu, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology and Medicine, 2021. (pdf)

6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer 

therapy of PEGylated indocyanine green, Qiang Hu, Kesi Wang, Liyan Qiu*, Colloids and Surfaces B: Biointerfaces, 2021. (pdf)

Vitamin E succinate with multiple functions: A versatile agent in nanomedicine-based cancer therapy and its 

delivery strategies, Lina Liang, Liyan Qiu*,International Journal of Pharmaceutics, 2021. (pdf)

Drug -driven self-assembly of pH-sensitive nano-vesicles with high loading capacity and anti-tumor efficacy, Yaomin Zhai, Juan Wang, Liyan Qiu*, Biomaterials Science, 2021. (pdf)

Mitochondria-targeted vitamin E succinate delivery for reversal of multidrug resistance, Lina Liang, Yan Peng, Liyan Qiu*, Journal of Controlled Release, 2021. (pdf)

Polymeric nano-vesicles via intermolecular action to load and orally deliver insulin with enhanced hypoglycemic effect, Yumiao Hu,  Juan Wang, Liyan Qiu*, RSC Advances, 2020. (pdf)

Nano-vesicles based on phospholipid-like amphiphilic polyphosphazenes to orally deliver ovalbumin antigen for evoking anti-tumor immune response, Yurun Shen, Yumiao Hu, Liyan Qiu*, Acta Biomaterialia, 2020. (pdf)

Polymersomes: Preparation and Characterization, Yumiao Hu, Liyan Qiu*, Pharmaceutical Nanotechnology, 2019. (pdf)

Effective oral delivery of gp100 plasmid vaccine against metastatic melanoma through multi-faceted blending-by-blending nanogels，Jun Fu, Liyan Qiu*,Nanomedicine: Nanotechnology, Biology and Medicine, 2019. (pdf)

Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes, Menghua Gao, Yan Peng, Liming Jiang, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology and Medicine, 2018. (pdf)

Design of pH-Sensitive Nanovesicles via cholesterol analogue incorporation for improving in vivo delivery of chemotherapeutics, Lina Liang, Jun Fu, Liyan Qiu*, ACS Applied Materials & Interfaces, 2018. (pdf)

Optimizing Hydrophobic Groups in Amphiphiles to Induce GoldNanoparticle Complex Vesicles for Stability Regulation, Jun Fu, Liyan Qiu*, Langmuir, 2017.(pdf)

Loading docetaxel in β-cyclodextrin-based micelles for enhanced oral chemotherapy through inhibition of P-glycoprotein mediated efflux transport, Lu Zhang, Yurun Shen, Liyan Qiu*, RSC Advances, 2017.(pdf)

Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles With Improved Inhibition Effect Toward S180 Tumors, Yurun Shen, Liping Wu, Liyan Qiu*, Journal of pharmaceutical sciences, 2017.(pdf)

In Situ Generated Gold Nanoparticle Hybrid Polymersomes for Water-Soluble Chemotherapeutics: Inhibited Leakage  and pH-Responsive Intracellular Release, Jun Fu, Lina Liang, Liyan Qiu*, Advanced Functional Materials, 2017.(pdf)

Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cance, Yan Peng, Xiumei Zhu, Liyan Qiu*, Biomaterials, 2016, 106: 1-12.(pdf)

Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal, Jing Xu, Xiumei Zhu,Liyan Qiu*, International journal of pharmaceutics, 2016, 498(1): 70-81.(pdf)

Constructing  aptamer anchored  nanovesicles  for  enhanced  tumor penetration  and  cellular uptake of  water soluble chemotherapeutics, Xin Li, Xiumei Zhu, Li Yan Qiu*, Acta Biomaterialia, 2016,35: 269-279 (pdf)  

Reverse micelles-in-microspheres with sustained release of water-soluble combretastatin A4 phosphate for S180 tumor treatment, Liping Wu, Liyan Qiu*, Journal of Materials Chemistry B, 2016, 4(4): 760-767.(pdf)

Polymersomes via Self-Assembly of Amphiphilic β-Cyclodextrin-Centered Triarm Star Polymers for Enhanced Oral Bioavailability of Water-Soluble Chemotherapeutics, Mengying Hu, Yurun Shen, Lu Zhang,Liyan Qiu*, Biomacromolecules, 2016, 17(3): 1026-1039.(pdf)

Mechanism study of PEGylated polyester and β-cyclodextrin integrated micelles on drug resistance reversal in MRP1-overexpressed HL60/ARD cells, Qian Ji, Liyan Qiu*, Colloids and Surfaces B: Biointerfaces, 2016, 144: 203-213 (pdf)

Weakly cationic polyphosphazene vesicles for cancer immunotherapy by efficient in vivo cytokine IL-12 plasmid DNA delivery, Menghua Gao, Xiumei Zhu, Liping Wu, Liyan Qiu, Biomacromolecules, 2016, 17(6), 2199-2209(pdf)

Optimizing particle size of docetaxel-loaded micelles for enhanced treatment of oral epidermoid carcinoma, Yang Yu, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology, and Medicine, 2016,12: 1941-1949 (pdf)

Multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Menghua Gao, Yuzhen Xu, Liyan Qiu*, Journal of Liposome Research (pdf)

Synergistic effects of A-B-C type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma, Lu Zhang, Jiafei Lu, Liyan Qiu*, International Journal of Nanomedicine (pdf)

Reversal of P-glycoprotein-mediated multidrug resistance by doxorubicin and quinine co-loaded liposomes in tumor cells, Qiying Shen, Liyan Qiu*,  Journal of Liposome Research, 2016: 1-9.

Sequentially dual-targeting vectors with nano-in-micro structure for improved docetaxel oral delivery in vivo, Yurun Shen,  Mengying Hu, Liyan Qiu*, Nanomedicine (pdf)

Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when coencapsulated with quinine in liposomes, Yuzhen Xu, Liyan Qiu*, International journal of nanomedicine, 2015, 10: 4225. (pdf)

The anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivates, Yang Yu, Xiaoli Zhang, Liyan Qiu*, Biomaterials 2014, 35:3467-3479 (pdf)

Thermosensitive micelles self-assembled by novel N-isopropylacrylamide oligomer Grafted Polyphosphazene, Jian Xiang Zhang, Li Yan Qiu*, Kang Jie Zhu, Yi Jin, Macromolecular Rapid Communications 2004, 25: 1563–1567 (pdf)