朱蔚璞副教授

日期:2009-07-28 10:10



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     朱蔚璞  副教授、博士生导师

 

个人简介:

 

  朱蔚璞,男,197910月生,江苏常熟人,理学博士,副教授、博士生导师。目前主要从事反应性高分子的合成及其应用研究,致力于开发规模化可控合成反应性高分子的新方法,并开拓这类高分子在药物递送、组织修复、口腔材料等领域的应用。主持多项国家自然科学基金项目,获2018年浙江省杰出青年基金资助。在Chem Commun, J Mater Chem, Macromolecules, Biomacromolecules, Polym Chem 等学术刊物上发表学术论文70余篇,他引1000余次,H指数为23。获得国家发明专利授权6项。

 

 

 

 

 

    

联系方式:

浙江大学高分子科学与工程系高分子科学研究所 浙江 杭州 310027

电子邮箱: zhuwp@zju.edu.cn; carrols@163.com

电话:+86 13735471052

 

研究小组每年招收1-2名博士研究生、1-2名硕士研究生,请及早联系。

实验室地址:玉泉校区教八205、207

 

个人主页:http://mypage.zju.edu.cn/zhuweipu

 

工作经历

2007.12~至今:浙江大学高分子科学与工程学系副教授

2009.122010.12:美国卡内基梅隆大学K. Matyjaszewski课题组,访问学者

2005.112007.12:浙江大学高分子科学与工程学系,博士后,讲师

 

主要研究方向

1. 可控聚合与反应性高分子

2. 高分子纳米药物

3. 高分子口腔材料 

 

课程

高等有机化学

第一章    第二章    第三章    第四章    第五章    第六章

 

主要研究论文*为通讯作者)

2018

44

Xuefei Sun, Weipu Zhu*, Krzysztof Matyjaszewski*. Protection of Opening Lids: Very High Catalytic Activity of Lipase Immobilized on Core-Shell Nanoparticles. Macromolecules, 2018, 51 (2): 289-296

 

2017

43

Chao Zhang, Zhimin Ying, Qiaojie Luo, Hong Du, Ying Wang, Kai Zhang, Shigui Yan, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Poly(hexamethylene guanidine)-based hydrogels with long lasting antimicrobial activity and low toxicity. J Polym Sci Pol Chem, 2017, 55 (12): 2027-2035

 

42

Jian Sheng, Ying Wang, Lu Xiong, Qiaojie Luo, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Injectable doxorubicin-loaded hydrogels based on dendron-like beta-cyclodextrin-poly(ethylene glycol) conjugates. Polym Chem, 2017, 8 (10): 1680-1688

 

2016

41

Hong Du, Ying Wang, Xuxia Yao*, Qiaojie Luo, Weipu Zhu*, Xiaodong Li,* Zhiquan Shen. Injectable cationic hydrogels with high antibacterial activity and low toxicity. Polym Chem, 2016, 7 (36): 5620-5624

 

40

Ying Wang, Qiaojie Luo, Weipu Zhu*, Xiaodong Li*, Zhiquan Shen. Reduction/pH dual-responsive nano-prodrug micelles for controlled drug delivery. Polym Chem, 2016, 7 (15): 2665-2673

 

39

Lilong, Gao, Yadong Chen, Qiaojie Luo, Ying Wang, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Injectable camptothecin conjugated hydrogels with simultaneous drug release and degradation. RSC Adv, 2016, 6 (91): 94661-94668

 

38

Lilong, Gao, Xiaojun Li, Qiaojie Luo, Ying Wang, Weipu Zhu*, Zhiquan Shen, Xiaodong Li*. Injectable thiol-epoxy "click" hydrogels. J Polym Sci Pol Chem, 2016, 54 (17): 2651-2655

 

37

Ying Huang, Rui Sun, Qiaojie Luo, Ying Wang, Kai Zhang, Xuliang Deng, Weipu Zhu*, Xiaodong Li*, Zhiquan Shen.In situ fabrication of paclitaxel-loaded core-crosslinked micelles via thiol-ene "click" chemistry for reduction-responsive drug release. J Polym Sci Pol Chem, 2016, 54 (1): 99-107

 

2015

36

Lilong Gao, Guangyu Zha, Ying Wang, Qiaojie Luo, Weipu Zhu*, Zhiquan Shen, Xiaodong Li*. An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor. Polym Chem, 2015, 6 (48): 8240-8243

 

35

Lu Xiong, Qiaojie Luo, Ying Wang, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug. Chem Commun2015, 51 (78): 14644-14647

 

34

Weipu Zhu, Lu Xiong, Huan Wang, Guangyu Zha, Hong Du, Xiaodong Li*, Zhiquan Shen. Sustained drug release from an ultrathin hydrogel film. Polym Chem2015, 6 (40): 7097-7099

 

33

Weipu Zhu, Ying Wang, Xia Cai, Guangyu Zha, Qiaojie Luo, Rui Sun, Xiaodong Li* and Zhiquan Shen. Reduction-triggered release of paclitaxel from in situ formed biodegradable core-cross-linked micelles. J Mater Chem B, 2013, 3 (7): 3024-3031

 

2014

32

Ying Wang, Qiaojie Luo, Rui Sun, Guangyu Zha, Xiaodong Li, Zhiquan Shen and Weipu Zhu*. Acid-triggered drug release from micelles based on amphiphilic oligo(ethylene glycol)-doxorubicin alternative copolymer. J Mater Chem B, 2014, 2 (43): 7612-7619

 

31

Ying Huang, Guangyu Zha, Qiaojie Luo, Jianxiang Zhang, Feng Zhang, Xiaohui Li, Shifang Zhao, Weipu Zhu, Xiaodong Li*. The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability. Sci Rep, 2014, 4: 6172

 

30.

Huan Wang, Guangyu Zha, Hong Du, Lilong Gao, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Facile fabrication of ultrathin antibacterial hydrogel films via layer-by-Layer “click” chemistry. Polym Chem, 2014, 5 (22): 6489-6494

 

29.

Ying Wang, Qiaojie Luo, Lilong Gao, Hong, Du, Guangyu Zha, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. A facile strategy to prepare redox-responsive amphiphilic PEGylated prodrug with high drug loading content and low critical micelle concentration. Biomater Sci, 2014, 2 (10):1367-1376

 

28.

Saadyah Averick, Orsolya Karácsony, Jacob Mohin, Xin Yong, Nicholas M. Moellers, Bradley F. Woodman, Weipu Zhu, Ryan A. Mehl, Anna C. Balazs*, Tomasz Kowalewski*, and Krzysztof Matyjaszewski*. Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures. Angew Chem Int Edit, 2014, 53 (31): 8050-8055

 

27.

Rui Sun, Qiaojie Luo, Chen Gao, Ying Wang, Lilong Gao, Hong Du, Ying Huang, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. Facile fabrication of reduction-responsive nanocarriers for controlled drug release. Polym Chem, 2014, 5 (17): 4879-4883

 

26.

Hong Du, Guangyu Zha, Lilong Gao, Huan Wang, Zhiquan Shen, Xiaodong Li, Weipu Zhu*. Fully biodegradable antibacterial hydrogels via thiol-ene “click” chemistry. Polym Chem, 2014, 5 (13): 4002-4008 (Cover story, paper of the week)

 

25.

Weipu Zhu, Lilong Gao, Qiaojie Luo, Chen Gao, Guangyu Zha, Zhiquan Shen, Xiaodong Li*. Metal and light free “click” hydrogels for prevention of postoperative peritoneal adhesions. Polym Chem, 2014, 5 (5): 2018-2026

 

未标题-5.tif

24.

Lilong Gao, Qiaojie Luo, Ying Wang, Hong Du, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release. RSC Adv, 2014, 4 (8): 4177-4180

 

2013

23.

Weipu Zhu*, Hong Du, Ying Huang, Shuai Sun, Ning Xu, Huagang Ni, Xia Cai, Xiaodong Li, Zhiquan Shen. Cationic poly(ester-phosphoester)s: Facile synthesis and antibacterial properties. J Polym Sci Pol Chem, 2013, 51 (17): 3667-3673 (Spotlight)

 

22.

Chen Gao, Ying Wang, Pengfei Gou, Xia Cai, Xiaodong Li, Weipu Zhu*, Zhiquan Shen. Synthesis and characterization of resorcinarene-centered amphiphilic A8B4 miktoarm star copolymers based on poly(ε-caprolactone) and poly(ethylene glycol) by combination of CROP and “click” chemistry. J Polym Sci Pol Chem, 2013, 51 (13): 2824-2833

 

21.

Ying Wang, Hong Du, Lilong Gao, Huagang Ni, Xiaodong Li, Weipu Zhu*, Zhiquan Shen. Reductively and hydrolytically dual degradable nanoparticles by “click” crosslinking of a multifunctional diblock copolymer. Polym Chem, 2013, 4 (5): 1657-1663

 

20.

Yu Wang, Mingjiang Zhong, Weipu Zhu, Chi-How Peng, Yaozhong Zhang, Dominik Konkolewicz, Nicola Bortolamei, Abdirisak A. Isse, Armando Gennaro, Krzysztof Matyjaszewski*. Reversible-deactivation radical polymerization in the presence of metallic copper: comproportionation–disproportionation equilibria and kinetics. Macromolecules, 2013, 46 (10): 3793-3802

 

19.

Chi-How Peng, Mingjiang Zhong, Yu Wang, Yungwan Kwak, Yaozhong Zhang, Weipu Zhu, Matthew Tonge, Johannes Buback, Sangwoo Park, Pawel Krys, Dominik Konkolewicz, Armando Gennaro, Krzysztof Matyjaszewski*. Reversible-deactivation radical polymerization in the presence of metallic copper: activation of alkyl halides by Cu0. Macromolecules, 2013, 46 (10): 3803-3815

 

2012

18

Weipu Zhu*, Ying Wang, Shuai Sun, Qiujin Zhang, Xiaodong Li, Zhiquan Shen. Facile synthesis and characterization of biodegradable antimicrobial poly(ester-carbonate). J Mater Chem, 2012, 22 (23): 11785-11791

 

17.

Yaozhong Zhang, Yu Wang, Chihow Peng, Mingjiang Zhong, Weipu Zhu, Dominik Konkolewicz, Krzysztof Matyjaszewski*. Copper-mediated CRP of methyl acrylate in the presence of metallic copper: effect of ligand structure on reaction kinetics. Macromolecules, 2012, 45 (1): 78-86

 

16.

Kai Zhang, Ying Wang, Weipu Zhu*, Xiaodong Li, Zhiquan Shen. Synthesis, characterization, and micellization of PCL-g-PEG copolymers by combination of ROP and "click" chemistry via "Graft onto" method. J Polym Sci Pol Chem, 2012, 50 (10): 2045-2052

 

2011

15.

Weipu Zhu, Mingjiang Zhong, Wenwen Li, Hongchen Dong, Krzysztof Matyjaszewski*. Clickable stars by combination of AROP and aqueous AGET ATRP. Macromolecules, 2011, 44 (7): 1920-1926

 

14

Weipu Zhu, Alper Nese, Krzysztof Matyjaszewski*. Thermoresponsive star triblock copolymers by combination of ROP and ATRP: from micelles to hydrogels. J Polym Sci Pol Chem,2011, 49 (9): 1942-1952

 

13.

Weipu Zhu*, Shuai Sun, Ning Xu, Zhiquan Shen*. Synthesis, characterization, and properties of poly(ester-phosphoester)s by lanthanum triphenolate-catalyzed ring-opening copolymerization. J Polym Sci Pol Chem,2011,49(23):4886-4893

 

12.

Weipu Zhu*, Ying Wang, Qiujin Zhang, Zhiquan Shen*. Amphiphilic PEG-grafted poly(ester-carbonate)s: Synthesis and diverse nanostructures in water. J Polym Sci Pol Chem,2011,49(22):4987-4992

 

2010

11

Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). Biomacromolecules, 2010, 11 (4): 934-943

 

10.

Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Drug-grafted seven-arm amphiphilic star poly(epsilon-caprolactone-co-carbonate)-b-poly(ethylene glycol)s based on a cyclodextrin core: synthesis and self-assembly behavior in water. Polym Chem, 2010, 1 (8): 1205-1214

 

9.

Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Calixarene-centered amphiphilic A(2)B(2) miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol) synthesis and self-assembly behaviors in water. J Polym Sci Pol Chem, 2010, 48 (24): 5643-5651

 

8.

Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis and self-assembly of well-defined cyclodextrin-centered amphiphilic A(14)B(7) multimiktoarm star copolymers based on poly(epsilon-caprolactone) and poly(acrylic acid). J Polym Sci Pol Chem, 2010, 48 (14): 2961-2974

 

2009

7.

Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis, self-assembly and drug-loading capacity of well-defined drug-conjugated amphiphilic A2B2 type miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). J Polym Sci Pol Chem, 2009, 47 (24): 6962-6976

 

6.

Pengfei Gou, Weipu Zhu*, Ning Zhu, Zhiquan Shen*. Synthesis and characterization of novel resorcinarene-centered amphiphilic star-block copolymers consisting of eight ABA triblock arms by combination of ROP, ATRP, and click chemistry. J Polym Sci Pol Chem, 2009, 47 (11): 2905-2916

 

image description

2008

5.

Feng Chen, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Ring-opening copolymerization of ethylene carbonate and epsilon-caprolactone catalyzed by neodymium tris(2,6-di-tert-buty-4-methylphenolate): Synthesis, characterization, and dynamic mechanic analysis. J Polym Sci Pol Chem, 2008, 46 (12): 4050-4055

 

4.

Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis and characterization of well-defined cyclodextrin-centered seven-arm star poly(epsilon-caprolactone)s and amphiphilic star poly(epsilon-caprolactone-b-ethylene glycol)s. J Polym Sci Pol Chem, 2008, 46 (19): 6455-6465

 

3.

Pengfei Gou, Weipu Zhu*, Zhiquan Shen*. Synthesis and characterization of resorcinarene-centered eight-arm poly(epsilon-caprolactone) stars catalyzed by yttrium complex. J Polym Sci Pol Chem, 2008, 46 (6): 2108-2118

 

Thumbnail image of graphical abstract

2007

2.

Weihui Xie, Weipu Zhu, Zhiquan Shen*. Synthesis, isothermal crystallization and micellization of mPEG-PCL diblock copolymers catalyzed by yttrium complex. Polymer, 2007, 48 (23): 6791-6798

1.

Weipu Zhu, Weihui Xie, Xiaowei Tong, Zhiquan Shen*. Amphiphilic biodegradable poly(CL-b-PEG-b-CL) triblock copolymers prepared by novel rare earth complex: Synthesis and crystallization properties. Eur Polym J, 2007, 43 (8): 3522-3530

 

发明专利

1.

朱蔚璞徐宁,苟鹏飞,沈之荃. 利用稀土催化剂制备磷酸酯聚合物的方法. 专利号:ZL 2010 1 0040017.1,授权日:2012-02-01

2.

李晓东,朱蔚璞,李晓辉. 一种半互穿网络结构水凝胶敷料的制备方法及应用. 专利号:ZL 2009 1 0154053.8,授权日:2010-04-14

3.

朱蔚璞张秋瑾,沈之荃.一种季胺化的可降解抗菌剂的制备方法.  专利号:ZL 2011 1 0007713.7,授权日:2013-06-12

4.

朱蔚璞高利龙,李晓东,沈之荃. 可原位注射聚乙二醇型水凝胶及其制备方法. 专利号:ZL 2012 1 0395047.3,授权日:2014-01-08

5.

朱蔚璞高利龙,李晓东,沈之荃. 具有溶胶-凝胶转变特性的温敏型抗菌嵌段聚合物及其制备方法. 专利号:ZL 2013 1 0228264.8,授权日:2015-04-22

6.

朱蔚璞王欢,杜红,高利龙,沈之荃. 一种超薄抗菌水凝胶薄膜的制备方法 专利号:ZL 2013 1 0672291.4,授权日:2015-07-08

 

 

 

 



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