Liyan Qiu, Ph.D.
Professor, Vice Director of Ministry of Education (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization
Education
B.S. Pharmacy, Zhejiang University, Hangzhou, China (1991-1995)
Ph.D. Polymer Chemistry and Physics, Zhejiang University, Hangzhou, China (1995-2000)
Career
Instructor (2001-2002), Associate Professor (2002-2007),
Professor (2007-2013)College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Professor (2014 till now), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
Visiting Scholar (2005-2006), University of Utah, UT, USA
Research Areas
Novel drug delivery systems and biomaterials used as drug carriers, specially targeted delivery system for anticancer
drugs or genes, controlled release preparations for peptide and protein drugs, and self-assembly of amphiphilic
biopolymers for drug delivery.
Selected Publications (total more than 80 papers)
(1) Mechanisms of drug resistance reversal in dox-resistant MCF-7 Cells by pH-responsive amphiphilic polyphosphazene
containing diisopropylamino side groups, Li Yan Qiu*, Cheng Zheng and Qinghe Zhao, Molecular Pharmaceutics,
2012, 9 (5): 1109-1117
(2) β-cyclodextrin-centered star-shaped amphiphilic polymers for doxorubicin delivery，Li Yan Qiu*, Rong Juan Wang,
Cheng Zheng, Yi Jin, Le Qun Jin，Nanomedicine, 2010, 5 (2): 193-208
(3) Self-assembled polyethylenimine-graft-poly(ε-caprolactone) micelles as potential dual carriers of genes and anticancer
drugs, Li Yan Qiu, You Han Bae, Biomaterials,2007 (28): 4132-4142
(4) Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation, Jian Xiang Zhang,
Xiao Jing Li, Li Yan Qiu*, Xiao Hui Li, Mei Qiu Yan, Yi Jin and Kang Jie Zhu，Journal of Controlled Release,
2006, 116 (3): 322-329
(5) Thermosensitive micelles self-assembled by novel N-isopropylacrylamide oligomer Grafted Polyphosphazene,
Jian Xiang Zhang, Li Yan Qiu*, Kang Jie Zhu, Yi Jin，Macro. Rapid Commu. 2004, 25:1563–1567
Selected Projects
(1) Pharmaceutical Materials, National Natural Science Funds for Excellent Young Scholar
(2) Construction and antitumor activity evaluation of a novel siRNA delivery system to silence anti-apoptotic gene survivin using amphiphilic polyphosphazene with endosome membrane disruption capability,
National Natural Science Fundation
(3) The key technology for development of injectable pharmaceutical excipient used in drug sustained release
system and targeting system, Major scientific and technological special project for new drugs creation
(4) Novel drug delivery system and biopolymers as drug carriers, The Ministry of education program for New
Century Excellent Talents
(5) Amphiphilic cyclodextrin-based polymeric carriers to reverse drug resistance of cancer via P-gp inhibition, Ph.D.
Program Foundation of Ministry of Education of China
Book Chapters
(1) Biopolymers，Volume 9: Miscellaneous Biopolymers and Biodegradation of Synthetic Polymers，
Chapter 22：Biodegradation of polyphosphazenes 491-522, KJ Zhu，LY Qiu，Wiley-VCH, 2003
(2) Biomedical Applications of Polyphosphazenes, 15 Amphiphilic Polyphosphazenes as Drug Carriers,
Liyan Qiu, Cheng Zheng, 277-296, Wiley，June 2009
Selected Patents (The first originator，total 16 items)
(1) Enteric microspheres for oral administration (ZL200310122947.1)
(2) Thymosin-loaded enteric microspheres for oral administration (CN200510049015.8)
(3) The preparation and application of a novel amphiphilic polyphosphazene（CN200710070630.6）
(4) Freeze-dried liposomes of chloroquine（CN200810098922.5）
(5) The preparation and application of a novel amphiphilic polymer based on cyclodextrin（CN200810062355.8）
Awards
2003, Scientific research achievement award of Zhejiang University, Second-class
2004, the New Century 151 Talent Project
2009, Chinese Pharmaceutical Association-CSPC young pharmaceutics award
2011, Program for New Century Excellent Talents in University
2012, National Natural Science Funds for Excellent Young Scholar
Society Activity
Editorial Board Member for Chinese Journal of Modern Applied Pharmacy
Medicine Evaluation Expert of Zhejiang Province
Expert of Zhejiang Medical Packing Council
Reviewer for National Nature Science Foundation
Referee for several international Journals
Senior Member of Chinese Pharmaceutical Association
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