申请条件：具备高分子科学、生物材料、智能材料、纳米和胶体材料、组织工程、再生医学、细胞生物学、临床医学学科背景中的一项或多项，博士期间取得突出成绩。

待遇：15万年薪+奖励

联系人：高长有。个人简历请发送到cygao@zju.edu.cn；咨询电话：0571-87951108。

研究课题：智能响应性梯度医用高分子及其调控细胞迁移行为研究

细胞迁移是一个重要的生物学和生理过程，与免疫反应、创伤愈合和肿瘤转移等密切相关。细胞迁移行为受各类生物、化学、物理和基质软硬梯度信号的影响；同时细胞分泌细胞外基质，重塑甚至改变细胞外基质环境。本项目将制备具有智能响应性梯度材料，包括具有刺激响应性能、自适应性能和细胞选择性的梯度医用高分子材料；模拟体内环境，采用单细胞模型和细胞片、细胞团模型，研究智能响应性梯度材料对细胞迁移行为的调控规律和原理；阐明材料智能响应和细胞培养前后表面粘附的蛋白质的主要种类、数量和构象的时空演化规律，建立响应性梯度生物材料调控细胞迁移的方法、模型和理论；探索具有梯度和取向结构的可降解材料在典型组织如血管和神经修复中的应用。

研究课题：响应型聚合物胶体微粒的制备及其对细胞吞噬和功能的影响

开展响应型聚合物胶体微粒的制备、细胞吞噬和细胞功能变化的研究，包括响应型聚合物胶体微粒的制备及其在类细胞内环境下的响应；跟踪微粒的胞吞和细胞内响应过程，建立吞噬模型；考察吞噬微粒后对细胞活性、特征功能、表型和遗传特征的影响规律；研究微粒在动物体内的变化过程及其对组织形态功能的影响。

Postdoc fellow recruitment

Send your CV to Prof. Changyou Gao, cygao@zju.edu.cn.

Research project: Gradient polymeric biomaterials with stimuli-response for regulating the migration of cells

The cell migration is one of the important processes in biology and physiology, and takes a pivotal role in immune response, would healing and tumor metastasis. While it is mediated by various gradient cues including biological, chemical, physical, and matrix signals, the cell milieu is in turn remodeled as a result of dynamic secretion of extracellular matrix by cells. In this study, intelligent and gradient polymeric biomaterials such as stimuli-responsive, adaptive and cell-selective gradient biomaterials shall be prepared and used to regulate cell migration in an intelligent manner. To better mimic the physiological milieu in vivo, the models of single cell, cell sheet and cell clusters shall be adopted to explore the phenomena, discipline and mechanism of cell migration on the intelligent and gradient biomaterials. Adsorption of key proteins and their spatial and time evolution on the gradient biomaterials before and after the intelligent response and cell culture shall be clarified, which can be further correlated with the cell migration behaviors to figure out the mediating methods and models of the intelligent and gradient biomaterials. The gradient biomaterials with spatially aligned physical features are intended to be applied for repair and regeneration of typical tissues such as blood vessel and nerve in vivo.

Research Project:Fabrication of responsive polymeric colloidal particles and their influences on cellular uptake and functions

Understanding the correlation between the molecular structure and physicochemical properties of the responsive colloidal particles and their intracellular uptake and response is one of the most paramount perquisites for the applications. In this study, novel polymeric particles with tunable chemical structure and responsiveness to external stimuli (temperature, pH, ionic strength and biomolecular concentration) shall be designed and fabricated. Their in vitro cellular uptake and intracellular response process shall be clarified in terms of cellular uptake rate, amount, pathways and intracellular distribution. Studies also cover the responsiveness of the particles inside the cells. The alteration of cell viability, specific functions, phenotype and genetic toxicity shall be studied too. Cellular uptake and transportation principles shall be summarized and models shall be suggested. Finally, the in vivo tissue accumulation and alteration of the particles shall be studied in a rat model.