Polymer Synthesis: Hyperbranched Polymer, Sequence-controlled Macromolecule, Click Chemistry, Living Control Polymerization.

Hyperbranched polymers have a large number of peripheral functional groups, abundant intramolecular cavities and simple preparation method for diverse potential applications, such as material and bioscience. However, traditional hyperbranched polymer can only implement the functionalization of peripheral functional groups because of high intramolecular steric effect and limited reaction method, while the utilization of cavities remains inefficiency. Our group designed and synthesised segmented hyperbranched polymers (SHP) with loose backbone architecture which can be modified. Combined with high efficiency click chemistry, we got full-backbone SHPs with different functionality, and expand the application area of hyperbranched polymer. Based on SHPs, we synthesized four-dimensional hyperbranched polymer brush.

Our group combined reversible addition fragmentation chain transfer (RAFT) polymerization with self-condensing vinyl polymerization (SCVP), and synthesized SHPs with full-backbone tertiary amine group in one step. We came up with Menshutkin-Click reaction firstly, imported cationic and nitrine group on the backbone, and obtained 2 kinds of water-soluble and clickable amphipathy SHPs. Then we use alkyne-azide cycloaddition reaction to grafting side chain or functional small molecule on the backbone, and got a series of new topology functionality polymer, such as hydrophilic four-dimensional polymer brush, amphipathy hyperbranched polyelectrolyte and hyperbranched ATRP macroinitiator.