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| Congratulations to Shupeng She, Dahai Yu, Bo Li and Xing Liu on their successful defense of the doctoral dissertations |
| Time:2013-09-15 16:29 Source:未知 Author:polymer Click: |
It was September 10, 2013, which was a special day- the Teacher’s Day of China. The doctoral dissertation defenses of four students of our group -Shupeng She, Dahai Yu, Xing Liu and Bo Li were conducted successfully at the conference room of Polymer Building. Professor Zhikang Xu of Department of Polymer Science and Engineering was invited as chairman of the dissertation committee and the chief of the fourth Chemical Science Section of NSFC Jianhua Dong, Professor Youqing Shen of Department of Chemical Engineering, Professor Jinfu Wang of College of Life Sciences and Professor Lie Ma of Department of Polymer Science and Engineering as the committee members. At the beginning, Professor Changyou Gao on behalf of our group expressed our best wishes for a happy Teacher’s Day to all the teachers present. Soon afterwards, the four doctoral students introduced their work of the doctorate study period in turn.
Shupeng She mainly researched the shape change of polyelectrolyte multilayer microcapsules in response to external fields. Firstly, he investigated the deformation and recovery behaviors of spherical multilayer microcapsules squeezed through microchannel. After the basic deformation-recovery properties of spherical capsules were obtained, the RBC-like capsules were fabricated, which possessed excellent deformation-recovery properties under constricted microcapillary. Finally, the shrinkage of PAH/PSS capsules in alkaline solution containing Ca2+ was investigated, the shrinking mechanism was deduced and confirmed.
Dahai Yu mainly researched the interactions between PLGA colloidal particles and cells. He prepared PLGA particles coated with PEI and BSA and investigated the influence of surface charge on the internalization processes and intracellular fate of the particles and their influences on cells. Further, redox-responsive and pH-responsive PLGA particles systems were established respectively and the responsiveness of these particles inside cells were researched carefully.
Xing Liu combined siRNA technology with regenerative biological materials. Aiming at interfering TGF-β1 signal pathway, directing cell fates and ultimately inhibiting scarring, he fabricated a new kind of collagen-chitosan/silicone membrane bilayer dermal equivalent loaded with siRNA( RNAi-BDE). Then the evaluation of RNAi-BDE was conducted in vitro and in vivo. And in order to optimize RNAi-functionalized scaffolding matrix, he also researched the vital influence of the cellular microenvironment on the efficiency of siRNA transfection.
Bo Li optimized systematically the structure and performance of PLGA/fibrin gel system for cartilage repair. He constructed the PLGA/fibrin gel/MSCs/TGF-β1 system, the PLGA/fibrin gel/MSCs/(PEO-b-PLL/pDNA-TGF-b1) system and the PLGA/fibrin gel/MSCs/( lipofectamine/pDNA-TGF-b1) system to research the influence of PLGA molecular weight, optimize the active factor and to research the influence of composition of the scaffold respectively.
The four students presented content-rich and well-organized dissertation defenses. They were praised by the defense committee for their excellent presentation and performance when answering the questions. All the experts present made many suggestions and comments for their doctoral dissertations and had a lively discussion. After discussion, the dissertation committee agreed unanimously that the four students all successfully defended their dissertations and be conferred the doctor's degree. Congratulate the four doctoral students on their completing studies smoothly and hope the other students progress together to create more successful results in the further work and life!
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